Role of the HLA system in the association between multiple sclerosis and infectious mononucleosis.
Arch Neurol
; 68(4): 469-72, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21482926
ABSTRACT
OBJECTIVE:
To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations.DESIGN:
A prospective cohort study was conducted from October 1, 1999, through September 30, 2003.SETTING:
University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland. PATIENTS Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM. INTERVENTION Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1). MAIN OUTCOMEMEASURE:
Diagnosis of IM and allele frequency.RESULTS:
Allelic analysis showed that HLA-DRB1*0101 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*0101 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03).CONCLUSION:
HLA-DRB1*0101 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-A
/
Mononucleose Infecciosa
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article