[Anti-NMDA receptor paraneoplastic encephalitis: complete recovery after ovarian teratoma removal]. / Encefalitis paraneoplásica por anticuerpos contra el receptor de NMDA. Remisión completa después de la resección de un teratoma ovárico.
Rev Neurol
; 52(9): 536-40, 2011 May 01.
Article
em Es
| MEDLINE
| ID: mdl-21484725
ABSTRACT
INTRODUCTION:
A paraneoplastic syndrome characterized by neuropsychiatric symptoms, involuntary movements and seizures has been recently associated with antibodies targeting NMDA (N-methyl-D-aspartate) receptor in patients with an ovarian teratoma. Severe neurological impairment is frequent and treatment in the intensive care unit is often required because of ventilatory failure and life-threatening autonomic instability. Tumor removal is curative in many cases and neurological improvement is demonstrated shortly after surgery. CASE REPORT Here we report on a patient with paraneoplastic encephalitis manifested by unconsciousness and coreo-athetosic movements related to NMDA receptor antibodies associated with an immature ovarian teratoma grade III. She made a complete recovery after oophorectomy, intravenous immunoglobulin and corticosteroids.CONCLUSIONS:
Treatment of paraneoplastic syndromes is based on specific therapy for underlying tumor associated to immunomodulators. As in this case, anti-NMDA encephalitis may significantly improve after tumor removal and intra-venous immunoglobuline.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Teratoma
/
Receptores de N-Metil-D-Aspartato
/
Síndromes Paraneoplásicas do Sistema Nervoso
/
Encefalite
Limite:
Adult
/
Female
/
Humans
Idioma:
Es
Ano de publicação:
2011
Tipo de documento:
Article