Targeting the Wnt/ß-catenin signaling pathway in human cancers.

INTRODUCTION: The Wnt/ß-catenin signaling pathway plays a pivotal role in the regulation of cell growth, cell development and the differentiation of normal stem cells. Constitutive activation of the Wnt/ß-catenin signaling pathway is found in many human cancers, and is thus an attractive target for anti-cancer therapy. Specific inhibitors of this pathway have been keenly researched and developed. AREAS COVERED: This review discusses the potential of inhibiting the Wnt/ß-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. EXPERT OPINION: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/ß-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/ß-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/ß-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.