Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene.
Eur J Contracept Reprod Health Care
; 16(4): 241-7, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21506883
ABSTRACT
OBJECTIVES:
The study aimed at investigating the independent and the combined effects of the two common genetic variants in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C > T and 1298A > C, and their interaction with lifestyle factors on timing of menarche and natural menopause.METHODS:
Postmenopausal women (N = 792) were assessed for the association of the two genetic variants with age at menarche (AM). A subsample of 578 of them who had a natural menopause were further investigated for the association of the two genetic variants with age at natural menopause (ANM). Genotyping was done by means of the TaqMan(®) allelic discrimination method. The effect of genetic variants and of lifestyle factors on AM and ANM were calculated by linear regression models.RESULTS:
The study revealed no association between the individual or combined effects of the two genetic variants and AM or ANM. The genetic variant 677C > T showed a significant interaction effect with duration of breastfeeding on ANM (p = 0.047).CONCLUSION:
We were unable to replicate previous findings suggesting that the MTHFR gene influences the onset of menarche and natural menopause. The interaction effect between the 677C >T genetic variant and duration of breastfeeding on the timing of natural menopause requires further investigation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menarca
/
Menopausa
/
Polimorfismo de Nucleotídeo Único
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Estilo de Vida
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Aged
/
Child
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Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article