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Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
Ramsuran, Veron; Kulkarni, Hemant; He, Weijing; Mlisana, Koleka; Wright, Edwina J; Werner, Lise; Castiblanco, John; Dhanda, Rahul; Le, Tuan; Dolan, Matthew J; Guan, Weihua; Weiss, Robin A; Clark, Robert A; Karim, Salim S Abdool; Ahuja, Sunil K; Ndung'u, Thumbi.
Afiliação
  • Ramsuran V; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Clin Infect Dis ; 52(10): 1248-56, 2011 May.
Article em En | MEDLINE | ID: mdl-21507922
BACKGROUND: The Duffy-null trait and ethnic netropenia are both highly prevalent in Africa. The influence of pre-seroconversion levels of peripheral blood cell counts (PBCs) on the risk of acquiring human immunodeficiency virus (HIV)-1 infection among Africans is unknown. METHODS: The triangular relationship among pre-seroconversion PBC counts, host genotypes, and risk of HIV acquisition was determined in a prospective cohort of black South African high-risk female sex workers. Twenty-seven women had seroconversion during follow-up, and 115 remained HIV negative for 2 years, despite engaging in high-risk activity. RESULTS: Pre-seroconversion neutrophil counts in women who subsequently had seroconversion were significantly lower, whereas platelet counts were higher, compared with those who remained HIV negative. Comprising 27% of the cohort, subjects with pre-seroconversion neutrophil counts of <2500 cells/mm(3) had a ∼3-fold greater risk of acquiring HIV infection. In a genome-wide association analyses, an African-specific polymorphism (rs2814778) in the promoter of Duffy Antigen Receptor for Chemokines (DARC -46T > C) was significantly associated with neutrophil counts (P = 7.9 × 10(-11)). DARC -46C/C results in loss of DARC expression on erthyrocytes (Duffy-null) and resistance to Plasmodium vivax malaria, and in our cohort, only subjects with this genotype had pre-seroconversion neutrophil counts of <2500 cells/mm(3). The risk of acquiring HIV infection was ∼3-fold greater in those with the trait of Duffy-null-associated low neutrophil counts, compared with all other study participants. CONCLUSIONS: Pre-seroconversion neutrophil and platelet counts influence risk of HIV infection. The trait of Duffy-null-associated low neutrophil counts influences HIV susceptibility. Because of the high prevalence of this trait among persons of African ancestry, it may contribute to the dynamics of the HIV epidemic in Africa.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / HIV-1 / HIV / Receptores de Superfície Celular / Predisposição Genética para Doença / Sistema do Grupo Sanguíneo Duffy / Neutropenia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / HIV-1 / HIV / Receptores de Superfície Celular / Predisposição Genética para Doença / Sistema do Grupo Sanguíneo Duffy / Neutropenia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2011 Tipo de documento: Article