Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity.
Biochem Biophys Res Commun
; 408(3): 405-10, 2011 May 13.
Article
em En
| MEDLINE
| ID: mdl-21513701
ABSTRACT
The Marasmius oreades mushroom lectin (MOA) is well known for its exquisite binding specificity for blood group B antigens. In addition to its N-terminal carbohydrate-binding domain, MOA possesses a C-terminal domain with unknown function, which structurally resembles hydrolytic enzymes. Here we show that MOA indeed has catalytic activity. It is a calcium-dependent cysteine protease resembling papain-like cysteine proteases, with Cys215 being the catalytic nucleophile. The possible importance of MOA's proteolytic activity for mushroom defense against pathogens is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aglutininas
/
Marasmius
/
Cisteína Proteases
/
Lectinas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article