Your browser doesn't support javascript.
loading
Protective effect of beta-glucan on contrast induced-nephropathy and a comparison of beta-glucan with nebivolol and N-acetylcysteine in rats.
Koc, Eyup; Reis, Kadriye Altok; Ebinc, Fatma Ayerden; Pasaoglu, Hatice; Demirtas, Canan; Omeroglu, Suna; Derici, Ulver Boztepe; Guz, Galip; Erten, Yasemin; Bali, Musa; Arinsoy, Turgay; Sindel, Sukru.
Afiliação
  • Koc E; Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey. eyupkocmd@yahoo.com.
  • Reis KA; , Umit Mah. Meksika Cad. Cinar Sitesi 4/2, Umitköy, Ankara, Turkey. eyupkocmd@yahoo.com.
  • Ebinc FA; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Pasaoglu H; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Demirtas C; Department of Biochemistry, Gazi University Medical School, Ankara, Turkey.
  • Omeroglu S; Department of Biochemistry, Gazi University Medical School, Ankara, Turkey.
  • Derici UB; Department of Histology, Gazi University Medical School, Ankara, Turkey.
  • Guz G; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Erten Y; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Bali M; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Arinsoy T; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
  • Sindel S; Department of Nephrology, Gazi University Medical School, Ankara, Turkey.
Clin Exp Nephrol ; 15(5): 658-665, 2011 Oct.
Article em En | MEDLINE | ID: mdl-21519821
BACKGROUND: It has been shown that beta-glucan (BG), which has antioxidant and immunomodulatory effects, attenuats renal ischemia-reperfusion injury. We aimed to investigate whether BG might have a preventive role against the development of contrast-induced nephropathy and to compare its effect with nebivolol (Nb) and N-acetylcysteine (NAC). METHODS: Thirty-six Wistar albino female rats were randomly divided into six groups (n = 6 each): control, contrast media (CM), BG, BG + CM, Nb + CM, and NAC + CM. With the exception of control and CM groups, the others were given drugs orally once a day for 5 days. Kidney function parameters, inflammatory parameters, and serum and renal tissue oxidative stress markers were measured. RESULTS: Increases of serum creatinine and blood urea nitrogen levels were significantly higher (p < 0.05) in the CM group only. Absolute changes of serum creatinine levels in BG, BG + CM and Nb + CM groups were significantly lower than those in the CM group (p < 0.05). Serum levels of advanced oxidation protein products and malondialdehyde were significantly less (p < 0.05) in the BG group compared to the CM group. Histopathological lesions in the CM group were more advanced (p < 0.05). No significant differences between the BG + CM, Nb + CM and NAC + CM groups were found with regard to histopathological findings. CONCLUSION: This study suggests that BG protects or ameliorates against contrast-induced nephropathy. Its beneficial effects may be similar to or greater than those of Nb or NAC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Benzopiranos / Beta-Glucanas / Etanolaminas / Injúria Renal Aguda Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Benzopiranos / Beta-Glucanas / Etanolaminas / Injúria Renal Aguda Limite: Animals Idioma: En Ano de publicação: 2011 Tipo de documento: Article