Treatment of long bone non-unions with polytherapy: indications and clinical results.
Injury
; 42(6): 587-90, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21524745
ABSTRACT
The incidence of long bone non-unions has been estimated to range between 5 and 10%. Autologous bone graft usually harvested from the iliac crest continues to be the gold standard for biological enhancement of atrophic non-unions. However, its use has been hampered by minor and major donor site complications. Moreover despite possessing the properties of osteogenecity, osteoconductivity and some osteoinductivity the overall results of treatment have not been consistent with disappointing success rates at times. The concept of polytherapy for the treatment of non-unions, namely the simultaneous application of the three fundamental elements of the diamond concept, osteoprogenitor cells, growth factor and osteoconductive scaffold, appears to be an attractive alternative but more studies are desirable to validate this strategy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante Ósseo
/
Consolidação da Fratura
/
Proteínas Morfogenéticas Ósseas
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Transplante de Células-Tronco Mesenquimais
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Alicerces Teciduais
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Fraturas não Consolidadas
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article