[Hyperferritinemia, ferropenia and metabolic syndrome in a patient with a new mutation of gene TFR2 and another in gene FTL. A family study]. / Hiperferritinemia, ferropenia y síndrome metabólico en un paciente con una nueva mutación en el gen TFR2 y otra en el gen FTL. Estudio familiar.
Med Clin (Barc)
; 137(2): 68-72, 2011 Jun 11.
Article
em Es
| MEDLINE
| ID: mdl-21524769
ABSTRACT
BACKGROUND AND OBJECTIVES:
Hyperferritinemia is a common finding in clinical practice. This condition can be congenital or acquired, although it is not always associated with iron overload. Genetic hyperferritinemia is associated with iron overload, hereditary hemochromatosis, or cataracts that progress without iron overload (hereditary hyperferritinemia-cataract syndrome). Metabolic syndrome is associated with hyperferritinemia and mild iron overload, with no increase in transferrin saturation. We report a family with hyperferritinemia. PATIENTS ANDMETHODS:
We present the study of a family with dual hyperferritinemia (congenital and acquired) and an analysis of the genes involved in iron metabolism.RESULTS:
Patients with hereditary hyperferritinemia-cataract syndrome have the mutation c.-167C>T in the FTL gene; patients with metabolic syndrome present a new mutation in the TFR2 gene (c.1259G>A, p.Arg420His).CONCLUSIONS:
The phenotypic and genotypic diversity of hyperferritinemia makes it a diagnostic challenge for clinicians. Basic research and clinical research should be combined to ensure better patient care.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apoferritinas
/
Catarata
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Receptores da Transferrina
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Distúrbios do Metabolismo do Ferro
/
Síndrome Metabólica
/
Deficiências de Ferro
/
Mutação
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
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Humans
/
Male
Idioma:
Es
Ano de publicação:
2011
Tipo de documento:
Article