Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).
J Med Chem
; 54(10): 3492-9, 2011 May 26.
Article
em En
| MEDLINE
| ID: mdl-21528845
ABSTRACT
We report the design and concise synthesis, in two steps from commercially available material, of novel, bioactive derivatives of the enzyme cofactor nicotinamide adenine dinucleotide (NAD). The new synthetic dinucleotides act as sirtuin (SIRT) inhibitors and show isoform selectivity for SIRT2 over SIRT1. An NMR-based conformational analysis suggests that the conformational preferences of individual analogues may contribute to their isoform selectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sirtuína 1
/
Sirtuína 2
/
NAD
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article