Immune mediators of rotavirus antigenemia clearance in mice.
J Virol
; 85(15): 7937-41, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21593155
ABSTRACT
The immunological mediators that clear rotavirus antigenemia or viremia remain undefined. Immunodeficient mice and antibody transfer were used to test whether lymphocytes or rotavirus-specific serum antibodies are essential for resolving antigenemia. Clearance of antigenemia required lymphocytes, but neither T nor B lymphocytes were absolutely required. Transfer of convalescent-phase or nonneutralizing rotavirus-specific serum antibodies to the systemic compartment of severe-combined-immunodeficient (SCID) mice temporarily suppressed the onset or level of chronic rotavirus antigenemia. Our findings provide the first report demonstrating that clearance of rotavirus antigenemia and possibly viremia are mediated by multiple effector lymphocyte subsets and serum antibodies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rotavirus
/
Antígenos Virais
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article