Suppression by fucoidan of liver fibrogenesis via the TGF-ß/Smad pathway in protecting against oxidative stress.
Biosci Biotechnol Biochem
; 75(5): 833-40, 2011.
Article
em En
| MEDLINE
| ID: mdl-21597183
ABSTRACT
Fucoidan, a sulfated polysaccharide extracted from various types of brown seaweed, possesses a wide range of pharmacological properties. We investigated the protective effect of fucoidan on dimethylnitrosamine-induced liver fibrogenesis in rats and its mechanism. Liver fibrosis was induced by injecting DMN (10 mg/kg, 3 times per week, I.P.) for 4 weeks, and fucoidan was simultaneously administered (100 mg/kg, 3 times per week, P.O.). The anti-oxidative and anti-inflammatory effects of fucoidan were observed by relative mediators. Fucoidan improved liver fibrosis by inhibiting the expression of transforming growth factor beta 1 (TGF-ß(1))/Smad3 and the tissue inhibitor of metalloproteinase 1 (TIMP-1), and increasing the expression of metalloproteinase-9 (MMP-9). Fucoidan also significantly decreased the accumulation of the extracellular matrix (ECM) and collagen. These results suggest that fucoidan had an anti-fibrotic effect, which was exerted by inhibiting the TGF-ß/Smad pathway, as well as anti-oxidative and anti-inflammatory effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Transdução de Sinais
/
Fator de Crescimento Transformador beta
/
Estresse Oxidativo
/
Proteínas Smad
/
Cirrose Hepática
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article