pH-disintegrable polyelectrolyte multilayer-coated mesoporous silica nanoparticles exhibiting triggered co-release of cisplatin and model drug molecules.
Macromol Rapid Commun
; 32(14): 1082-9, 2011 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-21618323
ABSTRACT
We report on the fabrication of pH-disintegrable polyelectrolyte multilayer-coated mesoporous silica nanoparticles (MSN) capable of triggered co-release of cisplatin and model drug molecules. The outer polyelectrolyte multilayer was assembled from permanently cationic polyelectrolyte, poly(allyl amine hydrochloride) (PAH), and negatively charged polyelectrolyte, P(DMA-co-TPAMA), consisting of N,N-dimethylacrylamide (DMA) and 3,4,5,6-tetrahydrophthalic anhydride-functionalized N-(3-aminopropyl)methacrylamide (TPAMA) monomer units, which exhibits pH-induced charge conversion characteristics. Thus, the subtle alteration of solution pH from 7.4 to ≈5-6 can lead to the disintegration of outer polyelectrolyte multilayers, accompanied with the co-release of cisplatin and RhB.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Rodaminas
/
Portadores de Fármacos
/
Cisplatino
/
Sistemas de Liberação de Medicamentos
/
Dióxido de Silício
/
Eletrólitos
/
Nanopartículas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article