Celiac disease and gyneco-obstetrics complications: can serum antibodies modulate tissue transglutaminase functions and contribute to clinical pattern?
Am J Reprod Immunol
; 66(6): 476-87, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21623996
ABSTRACT
PROBLEM:
Untreated celiac disease (CD) is often associated with early miscarriages, infertility, and alterations in menstrual cycle. Tissue transglutaminase (tTG) antibodies could be involved by interfering with tTG transamidating activity and/or biological functions mediated by its interaction with fibronectin (FN). METHOD OF STUDY The correlation between the presence of extra-digestive disorders and the reactivity of sera against tTG-FN and its effects on tTG transamidating activity was analyzed in a group or 50 women with recently diagnosed CD.RESULTS:
Heterogeneous behavior was observed among serum samples derived from patients with different complaints, suggesting that differences in fine specificity patterns could condition clinical outcome. Sera from women with gynecological and/or obstetric problems induced significant inhibition of in vitro enzymatic activity in comparison with those without these kinds of disorders.CONCLUSIONS:
The significant correlation observed between serum effects and clinical profile suggests a putative involvement of tTG-specific antibodies in gynecological and/or obstetric disorders during active CD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Autoanticorpos
/
Doença Celíaca
/
Transglutaminases
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Doenças Urogenitais Femininas
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
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Female
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Humans
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Middle aged
/
Pregnancy
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article