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Neurokinin A is a specific and precocious inhibitor of water intake in neonatal rats.
Perfumi, M; Massi, M; Epstein, A N; de Caro, G.
Afiliação
  • Perfumi M; Institute of Pharmacology, University of Camerino, Italy.
Peptides ; 11(2): 339-44, 1990.
Article em En | MEDLINE | ID: mdl-2162534
Neurokinin A (NKA), which selectively inhibits only cellular dehydration (CD)-induced drinking in adult rats, exerts a more general antidipsogenic effect in pups in which it also inhibits drinking induced by angiotensin II (AII) or suckling deprivation (SD). The inhibition of drinking is precocious (1st-3rd day) and never involves the intake of milk. The inhibition of CD-induced drinking increases with age, while that of AII- or SD-induced drinking progressively decreases and disappears on day 12-15. In the rat, NKA is therefore a precocious and selective inhibitor of drinking behavior and its selectivity is achieved ontogenetically.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Água / Neurocinina A / Ingestão de Líquidos Limite: Animals Idioma: En Ano de publicação: 1990 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Água / Neurocinina A / Ingestão de Líquidos Limite: Animals Idioma: En Ano de publicação: 1990 Tipo de documento: Article