Resolution of quadruplex polymorphism by size-exclusion chromatography.
Curr Protoc Nucleic Acid Chem
; Chapter 17: Unit17.3, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21638270
ABSTRACT
This unit describes a method for separation of quadruplex species formed from the same sequence via size-exclusion chromatography (SEC). Polymorphism is inherent to quadruplex formation, and even relatively simple quadruplex-forming sequences, such as the human telomere sequence d(GGG(TTAGGG)(3)), can form a myriad of possible configurations. HPLC, especially using reversed-phase and anion-exchange methods, has been a mainstay of nucleic acids research and purification for many decades. These methods have been applied for separation of individual quadruplex species formed in a mixture from the same parent sequence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia em Gel
/
Cromatografia Líquida de Alta Pressão
/
Telômero
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article