Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by 1H STD NMR techniques.
Org Biomol Chem
; 9(14): 5047-50, 2011 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-21643588
ABSTRACT
The enantioselective binding of the (SSS)-Δ isomer of an yttrium(III) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD (1)H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D docking simulations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Albumina Sérica
/
Elementos da Série dos Lantanídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article