Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits.
Microvasc Res
; 82(2): 156-62, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21658393
ABSTRACT
AIM:
This study was performed 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBF(ICA)) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance.METHODS:
Experiments were performed on 10 crossbred male rabbits. Heart rate (HR), blood pressure (BP), left ventricle ejection fraction (LVEF), CBF(ICA), the systolic-diastolic blood volume fraction in the brain circulation (CBF(SDF)) and cc-TQ were recorded after glucagon and acetazolamide administration. cc-TQ was measured with near-infrared transillumination back scattering sounding (NIR-T/BSS), LVEF and CBF(SDF) with gated scintigraphy and BP and CBF(ICA) with electromagnetic pressure and flow transducers, respectively. Doses of drugs were chosen to exert a haemodynamic effect but not change BP or intracranial pressure.RESULTS:
Acetazolamide and glucagon evoked significant increases in cc-TQ, CBF(SDF), CBF(ICA), LVEF and HR. The following interdependencies were found 1) changes after acetazolamide administration compared to baseline CBF(SDF) vs. LVEF (r=0.73, p<0.05), cc-TQ vs. CBF(SDF) (r=-0.67, p<0.05), cc-TQ vs. LVEF (r=-0.76, p<0.05), 2) changes after glucagon administration compared to baseline CBF(ICA) vs. BP (r=0.73, p<0.05), CBF(SDF) vs. LVEF (r=0.87, p<0.05), cc-TQ vs. HR (r=0.85, p<0.05), cc-TQ vs. CBF(ICA) (r=-0.74, p<0.05).CONCLUSION:
In the absence of systemic BP changes, pial arteries are significantly affected by changes in CBF(ICA). Pial arteries counteract changes in CBF(ICA) and CBF(SDF). The ability of pial arteries to stabilise CBF(ICA) is impaired after acetazolamide administration. Changes in cardiac output directly affect the brain's microcirculation. NIR-T/BSS recordings allow for non-invasive assessment of changes in pial artery compliance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Velocidade do Fluxo Sanguíneo
/
Circulação Cerebrovascular
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article