Rolling ES cells down the Waddington landscape with Oct4 and Sox2.
Cell
; 145(6): 815-7, 2011 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-21663785
ABSTRACT
Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al. (2011) now show that two core components of the pluripotency circuit, Oct4 and Sox2, are also critical for germ layer fate choice.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article