[Airway hyperreactivity]. / Hyperreaktivita dýchacích ciest.
Cesk Fysiol
; 60(1): 4-13, 2011.
Article
em Sk
| MEDLINE
| ID: mdl-21688668
ABSTRACT
The airway hyperreactivity (AHR) is a symptom occurring in various diseases of the respiratory system. It is defined as an abnormal bronchoconstriction response to a different spectrum of biological, chemical and pharmacological stimuli. Pathogenesis of airway hyperreactivity is not well understood. The available literature data shows that in the AHR pathogenesis is important not only genetic predisposition or influence of combination environmental and genetic factors, but also the presence and activity of various inflammatory mediators and other endogenous factors (growth factors, nuclear transcription factors). In this process is also important role of neural regulation and release of pro-inflammatory neurotransmitters. Our aim was to provide a comprehensive overview of knowledge about the symptoms--from the risk factors and pathogenesis through the clinical importance to the need for better understanding new options in therapeutic interventions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiper-Reatividade Brônquica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Sk
Ano de publicação:
2011
Tipo de documento:
Article