Changes of nerve growth factor in amniotic fluid and correlation with ventriculomegaly.
Chin Med Sci J
; 26(2): 109-12, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21703119
ABSTRACT
OBJECTIVE:
To detect the change of nerve growth factor (NGF) level in human amniotic fluid during gestation, and to explore the relationship between this change and fetal ventriculomegaly (VM).METHODS:
The studied subjects (collected from 2004 to 2007) were divided into four groups, including the second-trimester pregnancy group (n=113), third-trimester pregnancy group (n=110), fetal cerebral VM group (n=12), and healthy control group (n=12) which matched with the VM group in gestational weeks. The amniotic fluid specimens were obtained during amniocentesis or cesarean section. The NGF levels in amniotic fluid were detected with enzyme-linked immunosorbent assay.RESULTS:
A significantly negative correlation was found between gestational age and the NGF level in amniotic fluid (r=−0.6149, P<0.0001). The NGF level in patients with fetal VM was significantly lower than that in healthy controls (33.95±29.24 pg/mL vs. 64.73±16.21 pg/mL, P=0.024).CONCLUSION:
NGF levels in amniotic fluid may be a sensitive marker for fetal VM.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Neural
/
Líquido Amniótico
/
Hidrocefalia
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article