Cladribine enhances apoptotic cell death in lung carcinoma cells over-expressing DNase γ.
Biol Pharm Bull
; 34(7): 1001-4, 2011.
Article
em En
| MEDLINE
| ID: mdl-21720004
ABSTRACT
Worldwide, lung cancer is the most common form of cancer and often has a poor prognosis. Establishment of effective therapies for lung cancer is a major concern in clinical cancer research. We compared the cytotoxic effects of chemotherapeutic agents including cisplatin, 5-fluorouracil, vinorelbine and cladribine, on a human lung cancer cell line, A549, and its derivative transfected with the DNase γ gene. We observed selective cytotoxicity of cladribine on the DNase γ-expressing sub-cell line of A549. Cladribine induces selective apoptosis in DNase γ-expressing A549 cells, which depends on activation of caspases. These results suggest that a combination therapy that includes cladribine along with the introduction of DNase γ has potential as a new therapeutic strategy for lung cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
/
Cladribina
/
Apoptose
/
Endodesoxirribonucleases
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article