JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer.
Cell Cycle
; 10(15): 2583-91, 2011 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-21734453
ABSTRACT
The AP-1 transcription factor complex has been implicated in a variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. We previously established that activation of the AP-1 family member JunD contributes to deregulated expression of the anti-apoptotic IL-6 gene in prostate cancer cells. We now show that inhibition of JunD in prostate cancer cells results in GADD45α- and γ-dependent induction of cell death and inhibition of tumor growth that is mediated at least partially via c-Jun N-terminal kinase (JNK) and p38 kinase activation. Apoptosis induction by dominant negative JunD and JNK and p38 kinase activation are impeded upon knock down of GADD45α and γ expression by small interfering RNA, most vividly demonstrating the central role of GADD45α and γ in JunD-mediated escape of prostate cancer cells from programmed cell death.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Proteínas Nucleares
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Proteínas Proto-Oncogênicas c-jun
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Apoptose
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Proteínas de Ciclo Celular
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Peptídeos e Proteínas de Sinalização Intracelular
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article