[Quality evaluation of artificial musk based on its inhibitory effect on cyclooxygenase-2].
Yao Xue Xue Bao
; 46(4): 438-42, 2011 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-21751497
ABSTRACT
The inhibitory ratio (1%) of artificial musk on cyclooxygenase-2 (COX-2) was determined by enzyme immunoassay (EIA). The dose-effect relationship between concentrations of artificial musk and 1% was established. It was found that artificial musk had obvious inhibitory action on COX-2. The concentration for 50% of maximum inhibitory effect (IC50) was about 2.26 mg x mL(-1). There was a good relationship between the logarithm concentrations of artificial musk and 1% when the concentrations of artificial musk ranged from 0.31-20.0 mg x mL(-1). The results indicated that this EIA method could be applied to evaluate the anti-inflammatory activity of artificial musk quickly, conveniently, sensitively and exactly. This paper provided a novel method and foundational research for the bioassay of artificial musk.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Monoinsaturados
/
Ciclo-Oxigenase 2
/
Inibidores de Ciclo-Oxigenase 2
/
Anti-Inflamatórios
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article