Proximity as a factor in the innervation of host brain regions by retinal transplants.
J Comp Neurol
; 300(2): 211-29, 1990 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-2175316
ABSTRACT
Embryonic mouse retinae transplanted to a variety of locations within the rostral midbrain of neonatal rats exhibit selective innervation of host visual nuclei when studied at maturity. Some of these nuclei (superior colliculus, nucleus of the optic tract, dorsal terminal nucleus) usually receive extensive transplant projections, others are innervated partially (dorsal division of the lateral geniculate nucleus, olivary pretectal nucleus, medial terminal nucleus), while a few (ventral division of the lateral geniculate nucleus, suprachiasmatic nucleus, intergeniculate leaflet) are not innervated at all. The selectivity of this innervation is largely independent of the transplant's position within the rostral brainstem, while the density of innervation of individual nuclei depends in part upon the proximity of the transplant to the nucleus and upon whether the host retinal projection to that nucleus is present or absent. These findings provide a foundation for further studies of the behavioral capabilities of retinal transplants, for developmental studies of factors responsible for the establishment of normal neural projections, and for examination of the immunological consequences of transplantation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Encéfalo
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article