Identification of 2-(4-pyridyl)thienopyridinones as GSK-3ß inhibitors.
Bioorg Med Chem Lett
; 21(16): 4823-7, 2011 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-21764580
ABSTRACT
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3ß inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Tiofenos
/
Quinase 3 da Glicogênio Sintase
/
Inibidores de Proteínas Quinases
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article