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Calcium-sensitive inactivation in the gating of single calcium channels.
Yue, D T; Backx, P H; Imredy, J P.
Afiliação
  • Yue DT; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Science ; 250(4988): 1735-8, 1990 Dec 21.
Article em En | MEDLINE | ID: mdl-2176745
ABSTRACT
Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Ativação do Canal Iônico / Cálcio / Coração Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 1990 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Ativação do Canal Iônico / Cálcio / Coração Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 1990 Tipo de documento: Article