An accurate, fast and robust method to generate patient-specific cubic Hermite meshes.
Med Image Anal
; 15(6): 801-13, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21788150
ABSTRACT
In-silico continuum simulations of organ and tissue scale physiology often require a discretisation or mesh of the solution domain. Cubic Hermite meshes provide a smooth representation of anatomy that is well-suited for simulating large deformation mechanics. Models of organ mechanics and deformation have demonstrated significant potential for clinical application. However, the production of a personalised mesh from patient's anatomy using medical images remains a major bottleneck in simulation workflows. To address this issue, we have developed an accurate, fast and automatic method for deriving patient-specific cubic Hermite meshes. The proposed solution customises a predefined template with a fast binary image registration step and a novel cubic Hermite mesh warping constructed using a variational technique. Image registration is used to retrieve the mapping field between the template mesh and the patient images. The variational warping technique then finds a smooth and accurate projection of this field into the basis functions of the mesh. Applying this methodology, cubic Hermite meshes are fitted to the binary description of shape with sub-voxel accuracy and within a few minutes, which is a significant advance over the existing state of the art methods. To demonstrate its clinical utility, a generic cubic Hermite heart biventricular model is personalised to the anatomy of four patients, and the resulting mechanical stability of these customised meshes is successfully demonstrated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Processamento de Imagem Assistida por Computador
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Biologia Computacional
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Coração
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article