REMiner: a tool for unbiased mining and analysis of repetitive elements and their arrangement structures of large chromosomes.
Genomics
; 98(5): 381-9, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21803149
ABSTRACT
Repetitive elements (REs) constitute a substantial portion of the genomes of human and other species; however, the RE profiles (type, density, and arrangement) within the individual genomes have not been fully characterized. In this study, we developed an RE analysis tool, called REMiner, for a chromosome-wide investigation into the occurrence of individual REs and arrangement of clusters of REs, and REMiner's functional features were examined using the human chromosome Y. The algorithm implemented by REMiner focused on unbiased mining of REs in large chromosomes and data interface within a viewer. The data from the chromosome demonstrated that REMiner is an efficient tool in regard to its capacity for a large query size and the availability of a high-resolution viewer, featuring instant retrieval of alignment data and control of magnification and identity ratio. The chromosome-wide survey identified a diverse population of ordered RE arrangements, which may participate in the genome biology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interface Usuário-Computador
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Sequências Repetitivas de Ácido Nucleico
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Cromossomos Humanos Y
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Mineração de Dados
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article