Value of pre-operative serum CA125 level for prediction of prognosis in patients with endometrial cancer.
Aust N Z J Obstet Gynaecol
; 51(5): 397-402, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21806586
ABSTRACT
BACKGROUND:
High pre-operative CA125 levels in women with endometrial cancer may be related to lymph node metastases and poor prognosis.AIM:
To evaluate whether pre-operative cancer antigen 125 (CA125) levels are associated with lymph node metastases and prognosis in endometrial cancer.METHODS:
One hundred and twenty women with endometrial cancer were retrospectively reviewed for pre-operative CA125 levels. The results were then correlated with the clinicopathological outcome.RESULTS:
An elevated CA125 (>40 U/mL) was significantly correlated with higher stage, higher grade, increased depth of myometrial invasion, lymph node metastases and the presence of lympho-vascular space involvement in endometrial cancer. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were significantly higher in women with endometrial cancer with CA125 ≤ 40 U/mL than those with CA125 > 40 U/mL (P < 0.001). When women were further stratified according to CA125 levels and lymph node status, OS and RFS were highest for those with CA125 ≤ 40 U/mL and without lymph node metastases, and lowest for those with lymph node metastases and CA125 > 40 U/mL (P < 0.001).CONCLUSION:
The testing of pre-operative CA125 levels may a useful prognostic tool in endometrial cancer management.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Neoplasias do Endométrio
/
Antígeno Ca-125
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article