4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Bioorg Med Chem Lett
; 21(18): 5342-6, 2011 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-21807507
ABSTRACT
Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Ureia
/
Proteínas Proto-Oncogênicas B-raf
/
Inibidores de Proteínas Quinases
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article