[Effects of ferulic acid on bFGF-treated PC12 cells].
Zhong Yao Cai
; 34(4): 572-5, 2011 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-21809545
ABSTRACT
OBJECTIVE:
To explore the effect and mechanism of ferulic acid on differentiation in bFGF-treated PC12 cells.METHODS:
The length of neurite outgrowth and the percentage of PC12 cells induced in the presence of 0 ng/mL or 1 ng/mL bFGF were assayed.RESULTS:
Compared with that of control group,ferulic acid could enhance the differentiation effect of bFGF (1 ng/mL) in PC12 cells (P < 0.01) and the enhancing effect could be blocked by the specific MAPK kinase inhibitor, PD98059.CONCLUSION:
Ferulic acid potentiates neurite outgrowth in bFGF-treated PC12 cells by MAPK-dependent signaling pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Diferenciação Celular
/
Fator 2 de Crescimento de Fibroblastos
/
Neuritos
/
Ácidos Cumáricos
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article