Evaluation of major depressive disorder in patients receiving chronic treatment with topical timolol.
Ophthalmologica
; 226(3): 157-60, 2011.
Article
em En
| MEDLINE
| ID: mdl-21832816
ABSTRACT
PURPOSE:
It was the aim of this study to evaluate the prevalence of major depressive disorder (MDD) in chronic glaucoma patients on a topical ß-blocker (timolol).DESIGN:
An observational case control study was performed.METHODS:
The subjects recruited were divided into 3 groups. Group I included 98 patients with chronic glaucoma on topical ß-blocker therapy, group II included 64 chronic glaucoma patients on prostaglandin analogues, and group III included 150 normal controls. All subjects were screened for MDD by the self-administered questionnaire Prime-MD Today (Primary Care Evaluation of Mental Disorders, New York, N.Y., USA).RESULTS:
The control group had a significantly higher age (p < 0.001) compared to the glaucoma patients on timolol or prostaglandin analogues; 9/98 patients (9.2%) on timolol, 1/64 patients (1.5%) on prostaglandins and 3/150 (2%) control subjects were screened positive for MDD. The odds ratios adjusted for age, sex and duration of glaucoma showed that patients on ß-blocker therapy were 6.4 and 4.9 times more likely to have depression compared to those on prostaglandin analogues and control subjects, respectively.CONCLUSIONS:
Glaucoma patients on topical timolol should be screened for depression and referred for appropriate psychiatric consultation and treatment if indicated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timolol
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Glaucoma de Ângulo Fechado
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Glaucoma de Ângulo Aberto
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Antagonistas Adrenérgicos beta
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Transtorno Depressivo
/
Anti-Hipertensivos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
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Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article