White matter integrity deficit in treatment-naïve adult patients with major depressive disorder.
East Asian Arch Psychiatry
; 21(1): 5-9, 2011 Mar.
Article
em En
| MEDLINE
| ID: mdl-21837850
ABSTRACT
OBJECTIVES:
The fronto-limbic system plays critical roles in cognitive functions, including emotion. This is supported by recent reports in the studies of major depressive disorder using diffusion tensor imaging of the brain. This study examined white matter integrity and correlations to cognitive function in treatment-naive adult patients with major depressive disorder.METHODS:
Fractional anisotropy values, derived from diffusion tensor imaging, were compared in 18 treatment-naïve adult patients with major depressive disorder and 18 well-matched healthy controls by voxel-based analysis. Correlation of fractional anisotropy with performance of cognitive tests was also analysed.RESULTS:
Lower fractional anisotropy values in the bilateral medial frontal gyri, right subgyral frontal and temporal lobes, and left middle frontal and cingulate gyri were observed in patients than in controls. However, no correlation between mean fractional anisotropy values and cognitive scores was found.CONCLUSION:
These findings support the notion that deficit of white matter integrity in the fronto-limbic system may be the neural substrate of major depressive disorder.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mapeamento Encefálico
/
Transtorno Depressivo Maior
/
Imagem de Tensor de Difusão
/
Bainha de Mielina
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article