Your browser doesn't support javascript.
loading
Alleged cases of vaccine encephalopathy rediagnosed years later as Dravet syndrome.
Reyes, Ila S; Hsieh, David T; Laux, Linda C; Wilfong, Angus A.
Afiliação
  • Reyes IS; Department of Pediatrics, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA. david.hsieh@us.af.mil
Pediatrics ; 128(3): e699-702, 2011 Sep.
Article em En | MEDLINE | ID: mdl-21844054
Dravet syndrome is a rare epileptic encephalopathy linked to mutations in SCN1A (neuronal sodium channel α1 subunit) and characterized by an onset in infancy with polymorphous seizure types and developmental decline. It was reported recently that a proportion of patients previously diagnosed with alleged vaccine encephalopathy might possess SCN1A mutations and clinical histories that enabled a diagnosis of Dravet syndrome, but these results have not been replicated. We present here the cases of 5 children who presented for epilepsy care with presumed parental diagnoses of alleged vaccine encephalopathy caused by pertussis vaccinations in infancy. Their conditions were all rediagnosed years later, with the support of genetic testing, as Dravet syndrome. We hope that these cases will raise awareness of Dravet syndrome among health care providers who care for children and adolescents and aid in earlier recognition and diagnosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsias Mioclônicas Tipo de estudo: Etiology_studies Limite: Adolescent / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsias Mioclônicas Tipo de estudo: Etiology_studies Limite: Adolescent / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article