RSK2 signaling in brain habenula contributes to place aversion learning.
Learn Mem
; 18(9): 574-8, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21852432
ABSTRACT
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
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Transdução de Sinais
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Habenula
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Proteínas Quinases S6 Ribossômicas 90-kDa
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article