Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Bioorg Med Chem Lett
; 21(19): 5870-5, 2011 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-21855335
ABSTRACT
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Proteínas Tirosina Quinases
/
Neoplasias da Mama
/
Inibidores de Proteínas Quinases
/
Imidazóis
/
Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article