Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems.
J Microencapsul
; 28(7): 595-604, 2011.
Article
em En
| MEDLINE
| ID: mdl-21861589
ABSTRACT
Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.1-0.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.1-0.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações de Ação Retardada
/
Quitosana
/
Composição de Medicamentos
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Nanocápsulas
/
Lipossomos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article