[The peculiarities of rat tissue reactions to intraperitoneal implants made out of biodegradable polyhydroxyalkanoates].
Morfologiia
; 139(2): 62-6, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21866810
ABSTRACT
The reaction of rat tissues to intraperitoneal placement of implants made out of biodegradable polyhydroxyalkanoates (PHA), was studied at different time points after the operation by the methods of light microscopy. It was found that after intraperitoneal PHA implant placement, the active adhesive process started leading to formation of fibrous adhesions between PHA implants and intestinal loops. When PHA implants were used in the form of films, they became surrounded by a thick fibrous capsule. As a result of PHA implant placement in the form of ultrathin fibers, the extensive foreign body granulomas with perifocal inflammation and sclerosis of surrounding tissues were formed. In these granulomas the polymer fragmentation and phagocytosis by macrophages with formation of giant cells of foreign body occured. It is concluded that PHA implants are not biodegradable and induce tissue reactions similar to those caused by other foreign bodies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose
/
Granuloma de Corpo Estranho
/
Implantes Experimentais
/
Implantes Absorvíveis
/
Poli-Hidroxialcanoatos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
Ru
Ano de publicação:
2011
Tipo de documento:
Article