New synthesis of spirocycles by utilizing in situ forming hypervalent iodine species.
Org Biomol Chem
; 9(20): 6899-902, 2011 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-21892505
ABSTRACT
A very effective spirocyclization procedure for installing nucleophiles (Nu = N(3), NO(2), SCN, SO(2)Tol, and halogens) via iodonium(III) salts has been developed using the combination of iodoarene and mCPBA. The high-yielding syntheses of the cyclohexadienone-type spirocyclic compounds 2 having varied functionalities in the skeletons have been achieved from the aryl alkynes 1 with the optimized bis(iodoarene) 3h.
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MEDLINE
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Compostos de Espiro
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Idioma:
En
Ano de publicação:
2011
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Article