Post-pandemic seroprevalence of pandemic influenza A (H1N1) 2009 infection (swine flu) among children <18 years in Germany.
PLoS One
; 6(9): e23955, 2011.
Article
em En
| MEDLINE
| ID: mdl-21915270
ABSTRACT
BACKGROUND:
We determined antibodies to the pandemic influenza A (H1N1) 2009 virus in children to assess the incidence of (H1N1) 2009 infections in the 2009/2010 season in Germany, the proportion of subclinical infections and to compare titers in vaccinated and infected children. METHODOLOGY/PRINCIPALFINDINGS:
Eight pediatric hospitals distributed over Germany prospectively provided sera from in- or outpatients aged 1 to 17 years from April 1(st) to July 31(st) 2010. Vaccination history, recall of infections and sociodemographic factors were ascertained. Antibody titers were measured with a sensitive and specific in-house hemagglutination inhibition test (HIT) and compared to age-matched sera collected during 6 months before the onset of the pandemic in Germany. We analyzed 1420 post-pandemic and 300 pre-pandemic sera. Among unvaccinated children aged 1-4 and 5-17 years the prevalence of HI titers (≥1â¶10) was 27.1% (95% CI 23.5-31.3) and 53.5% (95% CI 50.9-56.2) compared to 1.7% and 5.5%, respectively, for pre-pandemic sera, accounting for a serologically determined incidence of influenza A (H1N1) 2009 during the season 2009/2010 of 25,4% (95% CI 19.3-30.5) in children aged 1-4 years and 48.0% (95% CI 42.6-52.0) in 5-17 year old children. Of children with HI titers ≥1â¶10, 25.5% (95% CI 22.5-28.8) reported no history of any infectious disease since June 2009. Among vaccinated children, 92% (95%-CI 87.0-96.6) of the 5-17 year old but only 47.8% (95%-CI 33.5-66.5) of the 1-4 year old children exhibited HI titers against influenza A virus (H1N1) 2009.CONCLUSION:
Serologically determined incidence of influenza A (H1N1) 2009 infections in children indicates high infection rates with older children (5-17 years) infected twice as often as younger children. In about a quarter of the children with HI titers after the season 2009/2010 subclinical infections must be assumed. Low HI titers in young children after vaccination with the AS03(B)-adjuvanted split virion vaccine need further scrutiny.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article