Facile synthesis and in-vitro antimalarial activity of novel α-hydroxy hydrazonates.
Arch Pharm (Weinheim)
; 344(11): 755-64, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21932256
ABSTRACT
A series of previously unreported α-hydroxy hydrazonates were synthesized and tested for their antimalarial properties. Structure optimization of the antiplasmodially active α-hydroxy hydrazonate III furnished derivatives with strong in-vitro antimalarial activity against 3D7 strains of Plasmodium falciparum with IC(50) values lower than 2.0 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Hidrazonas
/
Antimaláricos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article