[Study of the mechanism of mutagenesis directed by phosphotriester analogs of oligonucleotides. The role of repair in mutagenesis]. / Issledovanie mekhanizmov mutageneza, napravlennogo fosfotriéfirnymi analogami oligonukleotidov. Rol' reparatsii v zakreplenii mutatsii.
Mol Biol (Mosk)
; 24(2): 460-6, 1990.
Article
em Ru
| MEDLINE
| ID: mdl-2194116
ABSTRACT
The mutation system has been suggested in an effort to test insertion and deletion mutants by changing the Lac-phenotype of bacterial colonies transformed by mutant DNA. This system also makes possible to determine heterozygotes and homozygotes among the mutants. The yield of mutants in shown to depend on the structure of the DNA heteroduplex region. The yield of deletion mutants is greater than that of insertion mutants. Heterozygotes prevail in mutant colonies (greater than 90%).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Compostos Organofosforados
/
Organofosfatos
/
Reparo do DNA
/
Mutagênicos
/
Mutação
Idioma:
Ru
Ano de publicação:
1990
Tipo de documento:
Article