Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats.
Turk J Gastroenterol
; 22(4): 408-13, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21948572
ABSTRACT
BACKGROUND/AIMS:
Partial hepatectomy is performed for the treatment of mass lesions in the liver. Lycopene, which is a carotenoid, is present in various physiologic processes. In this study, the effects of lycopene administration in partially hepatectomized rats were evaluated by assessing various oxidant/antioxidant parameters, remnant liver histology and plasma nitric oxide levels.METHODS:
Thirty Wistar albino adult male rats were randomly divided into three equal groups as Sham, Partial Hepatectomy and Lycopene-Administered + Partial Hepatectomy groups. Lycopene (4 mg/kg), which was dissolved in olive oil, was given to the rats per orally (via gavage tube) (0.1 ml) every day for 6 weeks before partial hepatectomy and for one week after partial hepatectomy. Tissue and blood samples were collected one week after partial hepatectomy.RESULTS:
Plasma malondialdehyde (p<0.001) and nitric oxide (p<0.05) levels in the lycopene-administered + partial hepatectomy group were significantly higher than in the partial hepatectomy group. Intraerythrocytic glutathione (p<0.001), plasma (p<0.001) and liver tissue Cu-Zn (p<0.05) superoxide dismutase levels of the lycopene-administered + partial hepatectomy group were significantly lower than in the partial hepatectomy group.CONCLUSIONS:
Lycopene administration could be harmful by increasing oxidative stress after partial hepatectomy.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carotenoides
/
Estresse Oxidativo
/
Hepatectomia
/
Fígado
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article