[Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa].

OBJECTIVE: To study prescription and technique of intragastric floating two-chamber osmotic pump tablets (TCOPT) of total alkaloids of Coptis chinensis and Evodia rutaecarpa and inspect release property in vitro. METHODS: The orthogonal experiment was designed to screen prescription and technique. RESULTS: The optimization of prescription and technique were as follows: the expanding agent was a mixture of PEO and HPMC as a ratio of 4:1; the osmotic agent in propelling layer contained sodium chloride 20 mg, PEG 400 in the cellulose acetate, 10%; coating membrane in core tablet, 9%. The release behavior of TCOPT coincidented with zero-level equation well and the character of controlled-release was transparent. CONCLUSION: TCOPT has good effect of controlled-release in vitro and the release behavior in vivo need to be inspected.