Reproductive factors and Parkinson's disease: a multicenter case-control study.
Mov Disord
; 26(14): 2563-6, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-21956541
ABSTRACT
BACKGROUND:
The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD).METHODS:
The FRAGAMP study is a large Italian multicenter case-control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression).RESULTS:
Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24-8.59; P = .01).CONCLUSIONS:
Our data suggest that oral contraceptives could increase the risk of PD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Neoplasias Uterinas
/
Menopausa
/
Terapia de Reposição de Estrogênios
/
Anticoncepcionais Orais Hormonais
/
Estrogênios
/
Leiomioma
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Middle aged
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article