Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.
Biosci Biotechnol Biochem
; 75(10): 2042-5, 2011.
Article
em En
| MEDLINE
| ID: mdl-21979086
ABSTRACT
Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Tiazinas
/
Proteínas de Bactérias
/
Benzoquinonas
/
Lactamas Macrocíclicas
/
Mutação
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article