[The in vitro effect of a combination of sulbactam with cephalothin and cefazolin on strains of Escherichia coli and Proteus mirabilis which produce beta lactamase]. / Ucinok kombinácií sulbaktámu s cefalotínom a cefazolínom in vitro na kmene Escherichia coli a Proteus mirabilis produkujúce betalaktamázy.
Bratisl Lek Listy
; 91(4): 303-8, 1990 Apr.
Article
em Sk
| MEDLINE
| ID: mdl-2198081
ABSTRACT
The effect of the combination of sulbactam, cephalothin, and cephazolin was studied in vitro on 88 strains of E. coli and 11 strains of P. mirabilis producing beta-lactamases. Quantitative susceptibility of the tested strains to cephalothin was examined by the disk dilution method and the effect of the combinations with sulbactam by the micromethod. The production of beta-lactamases was determined by the qualitative test with the chromogenic substrate PODAC. Of the total number of 160 E. coli strains beta-lactamases were established in 53.3% of the strains. Of the 47 P. mirabilis strains 23.4% were found to produce beta-lactamases. The effect of the combinations with sulbactam was assessed as synergistic, additive, indifferent or antagonistic. In the combination of sulbactam in the concentration of 16.0 mg/l with cephalothin and cephazolin a higher rate of synergistic and additive effect was recorded on both strains. In none of the combinations did sulbactam exert an antagonistic effect.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteus mirabilis
/
Beta-Lactamases
/
Sulbactam
/
Cefazolina
/
Cefalotina
/
Escherichia coli
Tipo de estudo:
Qualitative_research
Idioma:
Sk
Ano de publicação:
1990
Tipo de documento:
Article