Successful tacrolimus treatment following renal transplant in a HIV-infected patient with raltegravir previously treated with a protease inhibitor based regimen.
Drug Metabol Drug Interact
; 26(3): 139-41, 2011.
Article
em En
| MEDLINE
| ID: mdl-21980965
ABSTRACT
A HIV positive patient who received a cadaveric renal transplantation developed tacrolimus toxicity as manifest by renal failure and decreased consciousness. This was due to atazanavir and ritonavir therapy for her HIV inhibiting the CYP3A4 hepatic enzyme resulting in accumulation of tacrolimus. Her HIV treatment was switched to raltegravir which is metabolized by UGT1A1 which does not affect tacrolimus. Tacrolimus was then reintroduced, and follow-up at 1 year demonstrated successful immunosuppression and undetectable HIV viral loads.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
/
Infecções por HIV
/
Transplante de Rim
/
Tacrolimo
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Inibidores da Protease de HIV
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Fármacos Anti-HIV
/
Imunossupressores
Limite:
Female
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article