Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.
Vaccine
; 29(49): 9246-55, 2011 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-21983155
ABSTRACT
A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Orthomyxoviridae
/
Vírus da Influenza A Subtipo H1N1
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Vírus da Influenza A Subtipo H3N2
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Proteção Cruzada
/
Formação de Anticorpos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article